Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote
cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small …

To study the function behind the molecular arrangement of single integrins in cell adhesion,
we designed a hexagonally close-packed rigid template of cell-adhesive gold nanodots …

Cyclic peptides containing biologically active hormone sequences are suitable models for
studying conformation‐activity relationships. In such models the usual flexibility of peptide …

Integrin-mediated adhesion is regulated by multiple features of the adhesive surface,
including its chemical composition, topography, and physical properties. In this study we …

The α V β 3 integrin receptor plays an important role in human tumor metastasis and tumor-induced
angiogenesis. The in vivo inhibition of this receptor by antibodies or by cyclic …

The α V β 3 integrin is implicated in human tumor metastasis and in angiogenesis. The design
of low-molecular-mass α V β 3 antagonists by “spatial screening” led to the highly active …

The α v β 3 integrin is an important cell adhesion receptor involved in tumor-induced
angiogenesis and tumor metastasis. Here we describe the 18 F-labeling of the RGD-containing …

Cyclic Arg-Gly-Asp-Phe-Val peptides with either D-Phe or D-Val residues were 20- to more
than 100-fold better inhibitors of cell adhesion to vitronectin and/or laminin fragment P1 when …

Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of
glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic small …

Rotations and inversions in organic molecules are readily recognizable from the temperature
dependence of the NMR spectra. The study of the effects of substituents on the activation …