Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain
types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic …

Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and
more to differentiate benign from malignant focal lesions and it has been shown to be more …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Purpose: The PTEN gene at chromosome 10q23.3 is a tumor-suppressor genethat is inactivated
in several types of human tumors. Althoughmutation and homozygous deletion are the …

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been used
to treat non–small cell lung cancer (NSCLC). However, the overall response rate to EGFR …

Insulin-like growth factor-binding protein (IGFBP)-3 regulates apoptosis in an IGF-independent
fashion and has been shown to localize to nuclei. We cloned the nuclear receptor retinoid …

Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been
found to be effective against lung cancer in vitro, but clinical resistance to these agents has …

Quantitative determination and in situ monitoring of molecular chirality at extremely low
concentrations is still challenging with simple optics because of the molecular-scale mismatch …

This study examines the relationship between audit committee and board independence
and auditor resignations. Independent audit committee and board members, who are …

Background: Because lung cancer is the leading cause of cancer-related death, new approaches
for preventing and controlling the disease are needed. Chemoprevention approaches …