In this review we give an overview of current knowledge of 68 Ga-labeled pharmaceuticals,
with focus on imaging receptor-mediated processes. A major advantage of a 68 Ge/ 68 Ga …

OBJECTIVES: PET scintigraphy with 68 Ga-labelled analogs is of increasing interest in
Nuclear Medicine and performed all over the world. Here we report the characteristics of the …

Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but
cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. …

Background Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates
for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with …

An overview how to measure and to quantify radiolysis by the addition of quenchers and to
maintain Radio- Chemical Purity (RCP) of vulnerable methionine-containing regulatory …

Background Absorbed doses for α-emitters are different from those for β-emitters, as the high
linear energy transfer (LET) nature of α-particles results in a very dense energy deposition …

[ 177 Lu]Lu-DOTA-PSMA-617 for PRRT is subject to radiolysis and therefore loses receptor
affinity. This will be detrimental for treatment efficacy. In this study optimal quencher(s) (…

Background Targeted alpha therapy has been postulated to have great potential for the
treatment of small clusters of tumour cells as well as small metastases. Bismuth, an α-emitter with …

Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs has
become an established procedure for the treatment of patients suffering from inoperable …

For the sake of safety it would be desirable to store and transport the ready-for-use liquid
formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in …