[PDF][PDF] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

M Maruyama, H Shimada, T Suhara, H Shinotoh, B Ji… - Neuron, 2013 - cell.com
Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …

[PDF][PDF] High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies

…, M Shigeta, N Sahara, M Higuchi, H Shimada - Neuron, 2021 - cell.com
A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar …

Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease

T Mori, H Shimada, H Shinotoh, S Hirano… - Journal of Neurology …, 2014 - jnnp.bmj.com
Objective Neuropsychiatric symptoms affect many patients with Alzheimer's disease (AD). (
11 C)Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled the in …

PET quantification of tau pathology in human brain with 11C-PBB3

Y Kimura, M Ichise, H Ito, H Shimada… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a …

Reconstruction magnetic resonance neurography in chronic inflammatory demyelinating polyneuropathy

…, S Mitsuma, Y Iwai, K Watanabe, H Shimada… - Annals of …, 2015 - Wiley Online Library
To study distribution and patterns of nerve hypertrophy in chronic inflammatory
demyelinating polyneuropathy (CIDP), magnetic resonance neurography with 3‐dimensional …

[HTML][HTML] Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C] PBB3-PET …

H Shimada, S Kitamura, H Shinotoh, H Endo… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and
concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), …

[HTML][HTML] Alterations in autonomic nervous control of heart rate among tourists at 2700 and 3700 m above sea level

…, F Nishihara, T Shiga, H Shimada… - Wilderness & …, 2001 - journals.sagepub.com
Objectives Many travelers who are not specially trained for activities at high altitude are at
risk of physical problems, including cardiovascular disorders, when exposed to high-altitude …

In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study

…, ZK Wszolek, AJ Strongosky, H Shimada… - Parkinsonism & related …, 2010 - Elsevier
BACKGROUND: Microglial activation and disrupted neurotransmissions may herald
symptomatic manifestations in neurodegenerative tauopathies. METHODS: We investigated …

Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia

S Hirano, H Shinotoh, H Shimada, A Aotsuka… - Brain, 2010 - academic.oup.com
Corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia are
all part of a disease spectrum that includes common cognitive impairment and movement …

PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

K Takahata, Y Kimura, N Sahara, S Koga, H Shimada… - Brain, 2019 - academic.oup.com
Tau deposits is a core feature of neurodegenerative disorder following traumatic brain injury
(TBI). Despite ample evidence from post-mortem studies demonstrating exposure to both …