Hepatic transport of 99m Tc-mebrofenin through organic anion transport protein 1a and 1b (Oatp1a/1b)
and multidrug resistance protein 2 (Mrp2) was investigated by small-animal …

Powders for reconstitution of the next-generation non-nucleoside reverse transcriptase
inhibitor (NNRTI) TMC278 with low water solubility were developed by using a spray-dry …

In clinical practice, 25–30% of the patients treated with fluoropyrimidines experience severe
fluoropyrimidine‐related toxicity. Extensively clinically validated DPYD genotyping tests are …

BACKGROUND Two European centres report on human leukocyte antigen (HLA) typing of
preimplantation embryos for haematopoietic stem cell (HSC) transplantation: ‘UZ Brussel’ in …

Background Fluoropyrimidine treatment can result in severe toxicity in up to 30% of patients
and is often the result of reduced activity of the key metabolic enzyme dihydropyrimidine …

Background Fluoropyrimidine therapy including capecitabine or 5-fluorouracil can result in
severe treatment-related toxicity in up to 30% of patients. Toxicity is often related to reduced …

Antibiotic overprescribing is one of the main drivers of the global and growing problem of
antibiotic resistance, especially in primary care and for respiratory tract infections (RTIs). RTIs …

2127 Objectives The current study characterizes a non-invasive method to visualize and
quantify altered hepatobiliary transport by using organic anion transporting protein (Oatp1a/1b) …

Objective: This study explores the intricate relationship between cognitive functioning and
aggression, with a specific focus on individuals prone to reactive or proactive aggression. The …

… Frank Adamson’s father would not allow other enslaved men near his wife: “He sho’ was a
man; he run all de other niggers ’way from my mammy and took up wid her widout askin’ de …