User profiles for Hidde L. Ploegh
 | Hidde PloeghSenior Investigator, Program in Cellular and Molecular Medicine, Boston Children's … Verified email at childrens.harvard.edu Cited by 111154 |
Viral subversion of the immune system
This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …
viruses to elude immune detection and destruction. These include targeting of pathways for …
Viral strategies of immune evasion
HL Ploegh - Science, 1998 - science.org
The vertebrate body is an ideal breeding ground for viruses and provides the conditions that
promote their growth, survival, and transmission. The immune system evolved and deals …
promote their growth, survival, and transmission. The immune system evolved and deals …
A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4 + T cells, which provide such …
cannot generate high-affinity antibodies without T cell help. CD4 + T cells, which provide such …
[PDF][PDF] Genome-scale CRISPR-mediated control of gene repression and activation
…, EH Whitehead, C Guimaraes, B Panning, HL Ploegh… - Cell, 2014 - cell.com
While the catalog of mammalian transcripts and their expression levels in different cell types
and disease states is rapidly expanding, our understanding of transcript function lags behind…
and disease states is rapidly expanding, our understanding of transcript function lags behind…
CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the
intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which …
intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which …
[HTML][HTML] The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by
selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum (…
selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum (…
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
The human cytomegalovirus genome encodes proteins that trigger destruction of newly
synthesized major histocompatibility complex (MHC) class I molecules. The human …
synthesized major histocompatibility complex (MHC) class I molecules. The human …
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
…, MC Truttmann, AM Bilate, JR Ingram, HL Ploegh - Nature …, 2015 - nature.com
… We thank members of the Ploegh laboratory, especially N. Pishesha and F. Tafesse, for
critical reading of the manuscript; PA Koenig, LK Swee, CS Shivalila, H. … Hidde L Ploegh …
critical reading of the manuscript; PA Koenig, LK Swee, CS Shivalila, H. … Hidde L Ploegh …
Empty MHC class I molecules come out in the cold
MAJOR histocompatibility complex (MHC) class I molecules present antigen by transporting
peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T …
peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T …
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4− 8+ T cells
The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for
a transporter, presumed to be involved in the delivery of peptides across the endoplasmic …
a transporter, presumed to be involved in the delivery of peptides across the endoplasmic …