Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …

The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds
(5 Pt(II) and 2 Pt(IV) drugs] was evaluated in a 8.6-fold cisplatin (CDDP)-resistant human …

ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can
transport a wide variety of substrates across biological membranes in an energy-dependent …

Platinum-based chemotherapies such as cisplatin are used as first-line treatment for many
cancers. Although there is often a high initial responsiveness, the majority of patients …

Several in vitro and in vivo models have revealed the key role of CXCR4/CXCL12 axis in
tumor-stroma interactions. Stromal cells present in the tumor microenvironment express high …

Vascular endothelial growth factor (VEGF)-A is overexpressed in most malignant and
premalignant breast lesions. VEGF-A can be visualized noninvasively with PET imaging and using …

Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …

Angiogenesis is a critical step in tumor development, in which vascular endothelial growth
factor (VEGF) is a key growth aspect. Heat shock protein 90 (HSP90), a molecular chaperone, …

In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired
lymphatic drainage that is associated with increased vascular permeability and enhanced …

NVP-AUY922, a potent heat shock protein (HSP) 90 inhibitor, downregulates the expression
of many oncogenic proteins, including the human epidermal growth factor receptor-2 (HER2…