Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most
prominent features are interdigitated foot processes with filtration slits in between. These …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Apoptosis plays a pivotal role in tissue homoeostasis both under physiological and pathological
conditions and several studies have shown that some characteristic changes in the …

Mature podocytes are among the most complex differentiated cells and possess a highly
branched array of foot processes that are essential to glomerular filtration in the kidney. Such …

Importance Optimal timing of initiation of renal replacement therapy (RRT) for severe acute
kidney injury (AKI) but without life-threatening indications is still unknown. Objective To …

Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The
postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and …

Background Autosomal dominant polycystic kidney disease (ADPKD) is a slowly progressive
hereditary disorder that usually leads to end-stage renal disease. Although the underlying …

Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly
identify the human organic cation transporter 2 (hOCT2) as the critical transporter for cis-…

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects,
such as oto- and nephrotoxicity. Ototoxicity is a problem of special importance in children, …

Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity,
represent a major health issue. However, they remain poorly understood. Here we have …