A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six
hypervariable regions from the heavy- and light-chain variable domains of a rat antibody …

Background Type 1 diabetes mellitus is a T-cell–mediated autoimmune disease that leads
to a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …

The maintenance of transplantation tolerance induced in adult mice after short-term treatment
with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4 + T cells from …

Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal
antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4 + T …

Natural regulatory T cells (T reg ) represent a distinct lineage of T lymphocytes committed to
suppressive functions, and expression of the transcription factor Foxp3 is thought to identify …

This phase II study determined the efficacy and safety of alemtuzumab, a humanized anti-CD52
monoclonal antibody, delivered subcutaneously as first-line therapy, over a prolonged …

The emerging notion of environment-induced reprogramming of Foxp3 + regulatory T (Treg)
cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive …

From 1991–2002, we treated 58 patients with multiple sclerosis (MS) using the humanised
monoclonal antibody, Campath–1H, which causes prolonged T lymphocyte depletion. …

… Herman Waldmann. The errant description of suppressor T cells in the 1970s has been
followed by a general acceptance in the early 1990s that some CD4 + T cells can and do …

A novel nonmyeloablative conditioning regimen was investigated in 44 patients with
hematologic malignancies. The median patient age was 41 years. Many of the patients had high-…