Background: Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with
heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects of …

Background High levels of ketone bodies are associated with improved survival as observed
with regular exercise, caloric restriction, and—most recently—treatment with sodium–…

Aims The present study tested the hypothesis that metformin treatment may increase
myocardial efficiency (stroke work/myocardial oxygen consumption) in insulin‐resistant patients …

Myocardial external efficiency is the relation of mechanical energy generated by the left (or
right) ventricle to the consumed chemical energy from aerobic metabolism. Efficiency can be …

Background In type 2 diabetes, a decrease in myocardial glucose uptake (MGU) may lower
glucose oxidation and contribute to progression of chronic heart failure (CHF). However, it is …

Background— Currently, no pharmacological treatment can modify the natural history of aortic
valve stenosis (AS). This underlines the critical need to explore novel treatment strategies, …

Background Myocardial oxygen consumption (MVO 2 ) and its coupling to contractile work
are fundamentals of cardiac function and may be involved causally in the transition from …

Background The glucagon-like peptide-1 analog liraglutide increases heart rate and may
be associated with more cardiac events in chronic heart failure (CHF) patients. We studied …

Aims Myocardial external efficiency (MEE) is the ratio of cardiac work in relation with energy
expenditure. We studied MEE in patients with different aetiologies and stages of heart failure …

Background The aim of this study was to develop and validate an automated method for
extracting forward stroke volume (FSV) using indicator dilution theory directly from dynamic …