Computer-aided drug design (CADD) is one of the pivotal approaches to contemporary pre-clinical
drug discovery, and various computational techniques and software programs are …

N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone, and dichloromethane (DCM) are the
most widely used solvents for Fmoc solid-phase peptide synthesis (SPPS). These solvents …

Infectious diseases are the leading cause of mortality worldwide, with viruses in particular
making global impact on healthcare and socioeconomic development. In addition, the rapid …

The analysis of these peptides by therapeutic categories is an indication of the versatility of
peptides to tackle a large number of biochemical transgressions. Thus, boceprevir and …

3-Methyl-1-sulfonic acid imidazolium nitrate ([Msim]NO 3 ) as a new Brønsted acidic ionic
liquid and nitrating agent was prepared and used for the efficient nitration of aromatic …

Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong
treatment of HIV infection challenging. The emerging field of nanotechnology may play an …

The synthesis and evaluation of structural analogues and isosteres are of central importance
in medicinal and agricultural chemistry. The sulfonamide functional group represents one …

The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

The first synthesis and biological activity of a teixobactin analogue is reported. Substitution
of the unusual l-allo-enduracididine residue by the naturally occurring l-arginine was …