Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

WH Chen, WC Lo, WC Hsu, HJ Wei, HY Liu, CH Lee… - Biomaterials, 2014 - Elsevier
Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical
disability and imbalanced homeostasis in cartilage. For advanced treatments, biological …

Tissue‐engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF‐β1 in platelet‐rich plasma

…, WC Lo, JJ Lee, CH Su, CT Lin, HY Liu… - Journal of cellular …, 2006 - Wiley Online Library
Human intervertebral disc (IVD) degeneration often initiated from the human nucleus pulposus
(hNP) with aging leading to IVD destruction and extracellular matrix (ECM) depletion. …

Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma

WH Chen, HY Liu, WC Lo, SC Wu, CH Chi, HY Chang… - Biomaterials, 2009 - Elsevier
An ex vivo degenerative intervertebral disc (IVD) organ culture system was established for
the screening of disc regeneration agents. Its application was demonstrated by a stem cell …

The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis

HY Liu, ATH Wu, CY Tsai, KR Chou, R Zeng, MF Wang… - Biomaterials, 2011 - Elsevier
The aim of this study was to develop a new diagnostic and therapeutic approach for the
treatment of osteoporosis. Previously, we demonstrated that intraosseous transplantation of …

[HTML][HTML] FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells

HJ Wei, JA Nickoloff, WH Chen, HY Liu, WC Lo… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Several reports suggest that malignant cells generate phenotypic diversity through fusion with
various types of stromal cells within the tumor microenvironment. Mesenchymal stem cell (…

[HTML][HTML] Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

HJ Wei, R Zeng, JH Lu, WFT Lai, WH Chen, HY Liu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent
attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of …

The effect of diminished osteogenic signals on reduced osteoporosis recovery in aged mice and the potential therapeutic use of adipose-derived stem cells

HY Liu, JF Chiou, ATH Wu, CY Tsai, JD Leu, LL Ting… - Biomaterials, 2012 - Elsevier
Adipose-derived stem cells (ADSCs) have been shown to be pluoripotent and explored for
their usage in tissue engineering. Previously, we have established a cell-based approach …

Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

HY Liu, CF Huang, TC Lin, CY Tsai, SYT Chen, A Liu… - Biomaterials, 2014 - Elsevier
Aging is related to loss of functional stem cell accompanying loss of tissue and organ
regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence …

[HTML][HTML] Potential osteoporosis recovery by deep sea water through bone regeneration in SAMP8 mice

HY Liu, MC Liu, MF Wang, WH Chen, CY Tsai… - Evidence-Based …, 2013 - hindawi.com
The aim of this study is to examine the therapeutic potential of deep sea water (DSW) on
osteoporosis. Previously, we have established the ovariectomized senescence-accelerated …

Transplantation of embryonic fibroblasts treated with platelet-rich plasma induces osteogenesis in SAMP8 mice monitored by molecular imaging

…, ML Cheong, CM Lee, HY Liu… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The aim of this study was to develop a cell-based bone-regeneration approach evaluated
by molecular imaging and immunohistochemistry. Methods: Genetically modified NIH3T3 …