Circulating tumor cells (CTC) released into blood from primary cancers and metastases reflect
the current status of tumor genotypes, which are prone to changes. Here, we conducted …

PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with
homology to adhesion molecules tensin and auxillin. It recently has been suggested that …

With the increasing number of available predictive biomarkers, clinical management of cancer
is becoming increasingly reliant on the accurate serial monitoring of tumor genotypes. We …

The p16 gene, also referred to as MTS1, INK4, CDK4I, or CDKN2, at chromosome 9p21 has
recently been described as a tumor suppressor that may be involved in a wide range of …

Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive
assays for assessing transcription factor activity are lacking. Here we develop and …

The molecular basis of human leukemia is heterogeneous. Cytogenetic findings are increasingly
associated with molecular abnormalities, some of which are being understood at the …

Acute graft-versus-host disease (aGvHD) is a serious complication of allogeneic hematopoietic
stem cell transplantation (allo-HSCT). 1 Although aGvHD of any target organ represents …

We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase
(KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca …

Aberrant signaling caused by mutations in the RAS-RAF-MEK-ERK pathway and its upstream
activators critically contributes to human tumor development. Strategies, which aim at …

Background Therapy related myeloid neoplasms (t-MNs) are complex diseases originating
from an interplay between exogenous toxicities and a susceptible organism. It has been …