Synthesis of serotonin by a second tryptophan hydroxylase isoform

DJ Walther, JU Peter, S Bashammakh, H Hörtnagl… - Science, 2003 - science.org
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] is causally involved in multiple
central nervous facets of mood control and in regulating sleep, anxiety, alcoholism, drug …

Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions

…, C Zacher, W Schmid, M Zink, H Hörtnagl… - Journal of …, 2005 - Soc Neuroscience
Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the pathogenesis
of major depression. To mimic the human situation of altered GR function claimed for …

Growth retardation and altered autonomic control in mice lacking brain serotonin

…, R Sohr, K Tenner, H Hörtnagl… - Proceedings of the …, 2009 - National Acad Sciences
Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1
and TPH2. By genetically ablating TPH2, we created mice (Tph2 −/− ) that lack serotonin …

Angiotensin AT2 receptor protects against cerebral ischemia‐induced neuronal injury

J Li, J Culman, H Hörtnagl, Y Zhao… - The FASEB …, 2005 - Wiley Online Library
Several lines of clinical and experimental evidence suggest an important role of the
reninangiotensin system in ischemic brain injury although the cellular regulation of the angiotensin …

Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy

M Hochleitner, H Hörtnagl, CK Ng, H Hörtnagl… - The American journal of …, 1990 - Elsevier
The beneficial effects of physiologic dual-chamber (DDD) pacing in the treatment of end-stage
idiopathic dilated cardiomyopathy were evaluated in 16 patients in whom conventional …

Photodynamic therapy of nonresectable cholangiocarcinoma

…, M Hanft, U Wruck, V Fusco, JM Müller, H Hörtnagl… - Gastroenterology, 1998 - Elsevier
Background & Aims: Successful treatment in nonresectable Bismuth type III and IV
cholangiocarcinoma is seldom achieved. The aim of this study was to evaluate the effect of …

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death

…, R von Harsdorf, W Brück, H Hörtnagl… - Journal of …, 2001 - Soc Neuroscience
After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant
activation of the cell cycle machinery is thought to contribute to apoptosis in various conditions …

Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neurones

…, D Megow, U Dirnagl, H Hörtnagl… - Journal of …, 2005 - Wiley Online Library
Statins [3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors] exert
cholesterol‐independent pleiotropic effects that include anti‐thrombotic, anti‐inflammatory, and …

Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered …

…, C Zacher, UE Lang, FA Henn, H Hörtnagl… - Molecular Brain …, 2004 - Elsevier
The “neurotrophin hypothesis” of depression predicts that depressive disorders in humans
coincide with a decreased activity and/or expression of brain-derived neurotrophic factor (…

Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission

…, J Ebner, H Lassmann, E Roth, H Hörtnagl - Hepatology, 1989 - journals.lww.com
An imbalance of excitatory and inhibitory amino acid-ergic neurotransmission has been
suggested to play a role in the pathogenesis of hepatic encephalopathy. For further evaluation of …