TISlO is a primary response gene whose cDNA was cloned as a result of its rapid,
superinducible expression in Swiss 3T3 cells in response to 12-0-tetradecanoylphorbol-13-acetate. …

'Eicosanoid'is a term coined to describe compounds derived from C 20 fatty acids [1]. The
term is now generally used to identify the paracrine hormones derived from free arachidonic …

All nucleated eukaryotic cells exhibit ligand-induced, transcription-dependent changes in
phenotype. Even the single-celled yeasts respond to polypeptide mating factors by alterations …

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule
drugs is an important and currently unmet challenge. We have developed a method, drug …

Transcriptional induction by interferons requires the tyrosine and serine phosphorylation of
STAT transcription factors. The N-terminal region is highly homologous among the STAT …

Type I protein arginine methyltransferases catalyze the formation of asymmetric ω-N G ,N G -dimethylarginine
residues by transferring methyl groups fromS-adenosyl-l-methionine to …

The TIS21 immediate-early gene and leukemia-associated BTG1 gene encode proteins with
similar sequences. Two-hybrid analysis identified a protein that interacts with TIS21 and …

We are developing assays for noninvasive, quantitative imaging of reporter genes with
positron emission tomography (PET), for application both in animal models and in human gene …

Noninvasive molecular-imaging technologies are providing researchers with exciting new
opportunities to study small-animal models of human disease. With continued improvements …

Tumor-derived prostaglandin E 2 (PGE 2 ) modifies cytokine balance and inhibits host immunity.
We hypothesized that a high level of PGE 2 production by lung tumor cells is dependent …