Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …

Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic
diet provides an alternative energy substrate to the brain and has neuroprotective effects…

Dopamine D 1 receptors in the prefrontal cortex (PFC) are important for prefrontal functions,
and it is suggested that stimulation of prefrontal D 1 receptors induces an inverted U-shaped …

Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a …

Purpose The aim of this multicenter trial was to generate a [ 123 I]FP-CIT SPECT database
of healthy controls from the common SPECT systems available in Japan. Methods This study …

18 F-(E)-N-(3-iodoprop-2E-enyl)-2β-carbofluoroethoxy-3β-(4-methylphenyl)nortropane ( 18
F-FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine …

BackgroundAlthough electroconvulsive therapy (ECT) is widely used to treat psychiatric
disorders such as depression, its precise neural mechanisms remain unknown.AimsTo …

The dopamine hypothesis has been the most widely known theory concerning schizophrenia.
However, the exact mechanism including presynaptic dopaminergic activity and its …

Antipsychotic polypharmacy has been empirically used and a recent trend in favour of that
mode of therapy has been suggested for the treatment of schizophrenia. The clinical efficacy, …

Objective: The norepinephrine transporter has been suggested to play a crucial role in major
depressive disorder. However, norepinephrine transporter availability in major depressive …