Betrachtet man die in der Natur am häufigsten vorkommenden Verbindungen, so fällt auf,
dass die Bildung von Kohlenstoff‐Heteroatom‐Bindungen gegenüber der von Kohlenstoff‐…

[**] We thank Dr. Vladislav Litosh for carrying out preliminary work. Support from the
National Institutes of Health, National Institute of General Medical Sciences (GM 28384), the …

Examination of nature's favorite molecules reveals a striking preference for making carbon–heteroatom
bonds over carbon–carbon bonds—surely no surprise given that carbon dioxide …

During the last decade a number of powerful asymmetric reactions have emerged as a
result of the growing need to develop efficient and practical syntheses of biologically active …

Click chemistry is a modular approach that uses only the most practical and reliable chemical
transformations. Its applications are increasingly found in all aspects of drug discovery, …

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked
to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel …

Microreactor technology has shown potential for optimizing synthetic efficiency, particularly
in preparing sensitive compounds. We achieved the synthesis of an [ 18 F]fluoride-…

… 1 , John Muldoon, Ying-Chuan Lin, Steven M Silverman, William Lindstrom, Arthur J
Olson, Hartmuth C Kolb, MG Finn, K Barry Sharpless, John H Elder, Valery V Fokin …

The in situ click chemistry approach to lead discovery employs the biological target itself for
assembling inhibitors from complementary building block reagents via irreversible …

An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …