The function of the blood–testis barrier is to protect germ cells from harmful influences; thus,
it also impedes the delivery of chemotherapeutic drugs to the testis. The barrier has three …

Selection of the right drug for the right patient is a promising approach to increase clinical
benefit of targeted therapy with monoclonal antibodies (mAbs). Assessment of in vivo …

Permeability of the blood-brain barrier (BBB) is one of the factors determining the
bioavailability of therapeutic drugs. The BBB only allows entry of lipophilic compounds with low …

Purpose Multiparametric magnetic resonance imaging (mpMRI) is a well-established imaging
method for localizing primary prostate cancer (PCa) and for guiding targeted prostate …

Parkinson's disease (PD) is associated with a loss of neurons from the midbrain. The cause
of PD is unknown, but it is established that certain neurotoxins can cause similar syndromes. …

Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical
benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, …

… Harry Hendrikse … Harry Hendrikse … Harry Hendrikse; Development of [ 11 C]erlotinib
Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status. Clin …

Purpose Docetaxel is an important chemotherapeutic agent used for the treatment of
several cancer types. As radiolabelled anticancer agents provide a potential means for …

131 I-GMIB-anti-human epidermal growth factor receptor type 2 (HER2)-VHH1 is a targeted
radionuclide theranostic agent directed at HER2-expressing cancers. VHH1 is a single-…

Drug resistance is a major cause of chemotherapy failure in cancer treatment. One reason
is the overexpression of the drug efflux pump P-glycoprotein (P-gp), involved in multidrug …