Background Tamoxifen increases the risk of endometrial cancer. However, few studies have
produced reliable risk estimates by duration, dose, and recency of use, or addressed the …

Background Although women with endometrial cancer generally have a favourable prognosis,
those with high-risk disease features are at increased risk of recurrence. The PORTEC-3 …

Purpose Ovarian cancer patients with intra-tumoral CD3 + T-lymphocytes in primary tumor
tissue have a better prognosis. This study aims to analyze the presence and relative influence …

Vascular endothelial growth factor (VEGF), released by tumor cells, is an important growth
factor in tumor angiogenesis. The humanized monoclonal antibody bevacizumab blocks VEGF…

The standard radical treatment of patients with early‐stage vulvar carcinoma has changed
to wide local excision and inguinofemoral lymphadenectomy through separate incisions, …

Hereditary nonpolyposis colorectal cancer (HNPCC) (Amsterdam criteria) is often caused
by mutations in mismatch repair (MMR) genes, and tumors of patients with HNPCC show …

… Mourits, Marian JE MD; De Vries, Elisabeth GE MD, PhD; Willemse, Pax HB MD, PhD;
Ten Hoor, Klaske A.; Hollema, Harry MD, PhD; Van der Zee, Ate GJ MD, PhD …

Background Currently, all patients with vulvar cancer with a positive sentinel node undergo
inguinofemoral lymphadenectomy, irrespective of the size of sentinel-node metastases. Our …

The MSH6 gene is one of the mismatch-repair genes involved in hereditary nonpolyposis
colorectal cancer (HNPCC). Three hundred sixteen individuals who were known or suspected …

Recombinant human (rh) TNF-related apoptosis-inducing ligand (TRAIL) harbors potential
as an anticancer agent. RhTRAIL induces apoptosis via the TRAIL receptors TRAIL-R1 and …