Background Reaching the therapeutic target of remission or low-disease activity has
improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target …

Psoriatic arthritis (PsA) is an inflammatory joint disease that is distinct from other chronic
arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and seronegativity …

Collagen type II (CII) is a relevant joint‐specific autoantigen in the pathogenesis of
rheumatoid arthritis (RA). Whereas the reasons for the breakage of self tolerance to this major …

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis
(RA). However, their biological role in disease development is still unclear. To obtain insight …

Objective To analyze the fine specificity of IgG autoantibodies in sera from rheumatoid
arthritis (RA) patients for type II collagen (CII) epitopes that are arthritogenic in collagen‐induced …

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized
by a chronic autoimmune response in the joints. Using transgenic mice expressing human …

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and,
despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci …

A critical event in an immune response is the T cell recognition of peptides bound to major
histocompatibility complex (MHC) molecules on the surface of an antigen presenting cell (APC…

Objectives To determine the safety, tolerability and signs of efficacy of MOR103, a human
monoclonal antibody to granulocyte–macrophage colony-stimulating factor (GM-CSF), in …

Extensive genome‐wide association studies have recently shed some light on the causes of
chronic autoimmune diseases and have confirmed a central role of the adaptive immune …