Purpose The purpose of this paper was to review the available approaches for bone strength
assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights …

Osteoporosis represents a significant and increasing healthcare burden in Europe, but most
patients at increased risk of fracture do not receive medication, resulting in a large treatment …

Background Fractures in men are a major health issue, and data on the antifracture efficacy
of therapies for osteoporosis in men are limited. We studied the effect of zoledronic acid on …

Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

Context: Sclerostin is produced by osteocytes and inhibits bone formation through the Wnt/β-catenin-signaling
pathway. Only limited data are available on circulating sclerostin levels in …

Context: Vitamin D has been shown to influence cardiac contractility and myocardial calcium
homeostasis. Objectives: We aimed to elucidate whether insufficient vitamin D status is …

Dual-energy X-ray absorptiometry (DXA) is a two-dimensional imaging technology developed
to assess bone mineral density (BMD) of the entire human skeleton and also specifically …

This study used data from the International Costs and Utilities Related to Osteoporotic fractures
Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and …

Pre-clinical data have shown that osteoprotegerin (OPG) inhibits osteoclast function and
therefore plays an important role in bone remodelling. This study aimed to evaluate the clinical …

This study sought to determine whether the bone loss in untreated chronic obstructive
pulmonary disease (COPD) is associated with hypercapnia and/or respiratory acidosis. Bone …