The signal-to-background ratio (SBR) is the key determinant of sensitivity, detectability and
linearity in optical imaging. As signal strength is often constrained by fundamental limits, …

The field of nanotechnology holds great promise for the diagnosis and treatment of human
disease. However, the size and charge of most nanoparticles preclude their efficient …

Because of their large size compared to small molecules and their multifunctionality,
nanoparticles (NPs) hold promise as biomedical imaging, diagnostic, and theragnostic agents. …

Inorganic/organic hybrid nanoparticles are potentially useful in biomedicine, but to avoid
non-specific background fluorescence and long-term toxicity, they need to be cleared from the …

A longstanding problem in the field of image-guided surgery is the development of ideal
near-infrared (NIR) fluorophores. The heptamethine NIR fluorophore indocyanine green (ICG) …

The field of biomedical optics has matured rapidly over the last decade and is poised to make
a significant impact on patient care. In particular, wide-field (typically > 5 cm), planar, near-…

Conspectus Near-infrared (NIR) fluorescence light has been widely utilized in clinical imaging
by providing surgeons highly specific images of target tissue. The “NIR window” from 650 …

The conventional method for creating targeted contrast agents is to conjugate separate
targeting and fluorophore domains. A new strategy is based on the incorporation of targeting …

When designing drug carriers, the drug-to-carrier ratio is an important consideration,
because the use of high quantities of carriers can result in toxicity as a consequence of poor …

The field of nanotechnology holds great promise for the diagnosis and treatment of human
disease. However, the size and charge of most nanoparticles preclude their efficient …