User profiles for H. Kim Lyerly

Herbert Kim Lyerly

Professor, Duke University
Verified email at mc.duke.edu
Cited by 26586

Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC

HKIM LYERLY, DL REED, TJ MATTHEWS… - AIDS research and …, 1987 - liebertpub.com
Cytophilic antibodies which mediate antibody dependent cellular cytotoxicity (ADCC) against
envelope antigens of human immunodeficiency virus (HIV) can be found in seropositive …

[HTML][HTML] A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

…, A Delcayre, DH Hsu, JB Le Pecq, HK Lyerly - Journal of translational …, 2005 - Springer
Background There is a continued need to develop more effective cancer immunotherapy
strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum …

Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

SS Hwang, TJ Boyle, HK Lyerly, BR Cullen - Science, 1991 - science.org
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …

Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

R Yarchoan, KJ Weinhold, HK Lyerly, E Gelmann… - The Lancet, 1986 - Elsevier
In a 6-week clinical trial 4 dose regimens of 3'-azido-3'-deoxythymidine (AZT), a thymidine
analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients …

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA

…, D Boczkowski, M Morse, RI Cumming, HK Lyerly… - Nature …, 1998 - nature.com
Dendritic cells (DC) generated from the peripheral blood mononuclear cells of healthy
individuals or from cancer patients transfected with carcinoembryonic antigen (CEA) mRNA …

Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells

D Boczkowski, SK Nair, JH Nam, HK Lyerly, E Gilboa - Cancer research, 2000 - AACR
Unique patient-specific tumor antigens may constitute the dominant antigens in the antitumor
immune response. Hence, vaccination with the patient’s own repertoire of tumor antigens …

Migration of human dendritic cells after injection in patients with metastatic malignancies

…, G Akabani, N Niehaus, D Coleman, HK Lyerly - Cancer research, 1999 - AACR
Present clinical studies of active immunotherapy for malignancies using dendritic cells (DCs)
require elucidation of the sites where DCs localize after injection. We evaluated the pattern …

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

…, K Comatas, J Magnani, H Kim Lyerly… - Science translational …, 2016 - science.org
Breast cancer metastatic relapse can occur years after therapy, indicating that disseminated
breast cancer cells (BCCs) have a prolonged dormant phase before becoming proliferative. …

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

…, HK Lyerly, H Krishnan, H Ab Hamid, H Yasaei… - …, 2015 - academic.oup.com
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Use of paravertebral block anesthesia in the surgical management of breast cancer: experience in 156 cases

…, JD Iglehart, GS Leight, SM Steele, HK Lyerly - Annals of …, 1998 - journals.lww.com
Objective To assess safety and efficacy of the regional anesthetic technique paravertebral
block for operative treatment of breast cancer, and to compare postoperative pain, nausea, …