Immuno-PET: a navigator in monoclonal antibody development and applications

GAMS Van Dongen, GWM Visser… - The …, 2007 - academic.oup.com
Learning Objectives After completing this course, the reader will be able to: Discuss the
technical advances that have led to recent rapid developments in monoclonal antibody imaging …

[HTML][HTML] PET imaging with radiolabeled antibodies and tyrosine kinase inhibitors: immuno-PET and TKI-PET

GAMS van Dongen, AJ Poot, DJ Vugts - Tumor Biology, 2012 - Springer
During the last decade, the discovery of critical tumor targets has boosted the design of
targeted therapeutic agents with monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (…

Immuno-positron emission tomography: shedding light on clinical antibody therapy

GAMS van Dongen, MJWD Vosjan - Cancer biotherapy & …, 2010 - liebertpub.com
Summation Monoclonal antibodies (mAbs) have been approved for therapeutic use in a
broad range of medical indications, especially in oncology, and are forming the most rapidly …

A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth

…, AJ Verkleij, GAMS van Dongen… - … journal of cancer, 2011 - Wiley Online Library
The epidermal growth factor receptor (EGFR) has been shown to be a valid cancer target for
antibody‐based therapy. At present, several anti‐EGFR monoclonal antibodies have been …

[HTML][HTML] Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

…, F Manca, DJ Vugts, B Windhorst, GAMS van Dongen… - PloS one, 2014 - journals.plos.org
Brain cancer is a devastating disease affecting many people worldwide. Effective treatment
with chemotherapeutics is limited due to the presence of the blood-brain barrier (BBB) that …

89Zr immuno-PET: comprehensive procedures for the production of 89Zr-labeled monoclonal antibodies

…, GB Snow, GAMS Van Dongen - Journal of nuclear …, 2003 - Soc Nuclear Med
The use of immuno-PET, the combination of PET with monoclonal antibodies (mAbs), is an
attractive option to improve tumor detection and mAb quantification. The long-lived positron …

The novel AML stem cell–associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells

A Van Rhenen, GAMS Van Dongen… - Blood, The Journal …, 2007 - ashpublications.org
In CD34 + acute myeloid leukemia (AML), the malignant stem cells reside in the CD38 −
compartment. We have shown before that the frequency of such CD34 + CD38 − cells at …

Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine

…, M Budde, P Jurek, GE Kiefer, GAMS Van Dongen - Nature protocols, 2010 - nature.com
The positron emitter zirconium-89 ( 89 Zr) has very attractive properties for positron
emission tomography (PET) imaging of intact monoclonal antibodies (mAbs) using immuno-PET. …

Development and characterization of clinical-grade 89Zr-trastuzumab for HER2/neu immunoPET imaging

…, LR Perk, GAMS van Dongen… - Journal of nuclear …, 2009 - Soc Nuclear Med
The anti–human epidermal growth factor receptor 2 (HER2/neu) antibody trastuzumab is
administered to patients with HER2/neu-overexpressing breast cancer. Whole-body …

Improved tumor targeting of anti–epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

…, HJ de Haard, CR Leemans, GAMS van Dongen - Molecular cancer …, 2008 - AACR
The ∼15-kDa variable domains of camelid heavy-chain-only antibodies (called Nanobodies)
can easily be formatted as multivalent or multispecific single-chain proteins. Because of …