Background Δ6-Desaturase (Fads2) is widely regarded as rate-limiting in the conversion of
dietary α-linolenic acid (18:3n-3; ALA) to the long-chain omega-3 polyunsaturated fatty acid …

The health benefits of the (n-3) PUFA, EPA, and DHA have created a demand for fish and
fish oil, the main sources of these PUFA. Production animals, such as poultry, are potential …

The synthesis of the omega-3 long-chain polyunsaturated fatty acids (LCPUFA) eicosapentaenoic
acid (EPA; 20:5n− 3) and docosahexaenoic acid (DHA; 22:6n − 3) from dietary α-…

The investigation of cerebral metabolic rate of glucose (CMRGlu) at baseline and during
specific tasks previously required separate scans with the drawback of high intrasubject …

Aggregation of hyperphosphorylated tau is a major hallmark of many neurodegenerative
diseases, including Alzheimer disease (AD). In vivo imaging with PET may offer important …

Functional characterization of the rat elongases, Elovl5 and Elovl2, has identified that Elovl2
is crucial for omega-3 docosahexaenoic acid (DHA) (22:6n-3) synthesis. While the substrate …

Attention deficit hyperactivity disorder (ADHD) is a heterogeneous disorder with a strong
genetic component. The norepinephrine transporter (NET) is a key target for ADHD treatment …

Selective serotonin reuptake inhibitors (SSRIs) modulate serotonergic neurotransmission
by blocking reuptake of serotonin from the extracellular space. Up to now, it remains unclear …

Background Electroconvulsive therapy (ECT) constitutes one of the most effective
antidepressant treatment strategies in major depression (MDD). Despite its common use and …

In most Western countries, the consumption of fish is low and insufficient to provide the
recommended daily intake of the n–3 (ω-3) long-chain polyunsaturated fatty acids (PUFAs) …