[PDF][PDF] Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
…, N Sahgal, H Lockstone, D Baban, E Nye, GW Stamp… - Cancer cell, 2011 - cell.com
The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It has …
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It has …
Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression.
MS Naylor, GW Stamp, WD Foulkes… - The Journal of …, 1993 - Am Soc Clin Investig
The gene for tumor necrosis factor, TNF, was expressed in 45 out of 63 biopsies of human
epithelial ovarian cancer. In serous tumors, there was a positive correlation between level of …
epithelial ovarian cancer. In serous tumors, there was a positive correlation between level of …
Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes …
…, R Ramachandran, V Salem, GW Stamp… - The Journal of …, 2009 - academic.oup.com
Background: Kisspeptin is a critical regulator of normal reproductive function. A single
injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. …
injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. …
The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo
…, B Spencer-Dene, NR Lemoine, GW Stamp… - Cancer research, 2009 - AACR
Lung cancer is the commonest cancer killer. Small cell lung cancer (SCLC) is initially
chemosensitive, but rapidly relapses in a chemoresistant form with an overall survival of <5%. …
chemosensitive, but rapidly relapses in a chemoresistant form with an overall survival of <5%. …
[PDF][PDF] Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
…, I Rosewell, R Poulsom, P Maxwell, GW Stamp… - Cancer cell, 2007 - cell.com
Germline mutations in the fumarate hydratase (FH) tumor suppressor gene predispose to
leiomyomatosis, renal cysts, and renal cell cancer (HLRCC). HLRCC tumors overexpress …
leiomyomatosis, renal cysts, and renal cell cancer (HLRCC). HLRCC tumors overexpress …
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis
…, FK Mardakheh, A McCarthy, M Yeo, GW Stamp… - elife, 2016 - elifesciences.org
10.7554/eLife.12203.001 Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase
effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and …
effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and …
Wide-field fluorescence lifetime imaging of cancer
…, MAA Neil, PMW French, GW Stamp - Biomedical optics …, 2010 - opg.optica.org
Optical imaging of tissue autofluorescence has the potential to provide rapid label-free screening
and detection of surface tumors for clinical applications, including when combined with …
and detection of surface tumors for clinical applications, including when combined with …
Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations
…, MJ Gleeson, SV Hodgson, GW Stamp… - The Journal of …, 2006 - academic.oup.com
Context: Activation of the hypoxia-inducible transcription factors HIF-1 and HIF-2 and a HIF-independent
defect in developmental apoptosis have been implicated in the pathogenesis of …
defect in developmental apoptosis have been implicated in the pathogenesis of …
Chemokine‐cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract
…, FM Alam, M Nohadani, GW Stamp… - Molecular …, 2010 - Wiley Online Library
SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL‐8 and its activity is
associated with human invasive disease severity. We investigated the role of SpyCEP in S. …
associated with human invasive disease severity. We investigated the role of SpyCEP in S. …
Tumor–stromal cell communication: small vesicles signal big changes
Reciprocal interactions between malignant and stromal cells create a local microenvironment
that fosters tumor growth. Extracellular vesicles (EVs) such as exosomes, microvesicles, …
that fosters tumor growth. Extracellular vesicles (EVs) such as exosomes, microvesicles, …