The budding yeast Cdc6 protein (Cdc6p) is essential for formation of pre‐replicative complexes
(pre‐RCs) at origins of DNA replication. Regulation of pre‐RC assembly plays a key role …

Apoptosis is now widely recognized as a common form of cell death and represents a
mechanism of cell clearance in many physiological situations where deletion of cells is required. …

Background: Cdc28p, the major cyclin-dependent kinase in budding yeast, prevents re-replication
within each cell cycle by preventing the reassembly of Cdc6p-dependent pre-…

Expression of the Cdc6 protein (Cdc6p) is essential for formation of prereplicative complexes
at budding yeast replication origins. Analysis of mutations in the conserved nucleoside …

The Cdc6 DNA replication initiation factor is targeted for ubiquitin‐mediated proteolysis by the
E3 ubiquitin ligase SCF CDC4 from the end of G 1 phase until mitosis in the budding yeast …

The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) are
activated by pleiotropic signals including environmental stresses, growth factors, and …

GATA-2 is a member of a family of transcription factors which bind a common DNA sequence
motif (WGATAR) through an evolutionarily conserved zinc finger domain. An essential role …

Murine bone-marrow derived BAF3 cells, over-expressing the human Bcl-2 gene product,
showed considerably delayed onset of apoptosis when deprived of IL-3. Such Bcl-2-BAF3 …

Eukaryotic DNA replication is limited to once per cell cycle because cyclin-dependent kinases
(cdks), which are required to fire origins, also prevent re-replication. Components of the …

Alton Water, Suffolk, UK is a pumped storage reservoir that has a history of cyanobacterial
blooms. Dosing of the input water with ferric sulphate to control external phosphorus loading …