2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …

The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases remain …

Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary
tau tangles, but increasing evidence suggests that neuroinflammation also plays a key …

Background Corticobasal syndrome is associated with cerebral protein aggregates composed
of 4‐repeat (~50% of cases) or mixed 3‐repeat/4‐repeat tau isoforms (~25% of cases) or …

The novel tau-PET tracer [ 18 F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s
disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive …

Background Neuroinflammation has received growing interest as a therapeutic target in
neurodegenerative disorders, including 4‐repeat tauopathies. Objectives The aim of this cross‐…

β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the
major hallmarks of Alzheimer’s disease (AD), and biomarkers for these hallmarks have been …

Background In vivo assessment of neuroinflammation by 18-kDa translocator protein
positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and …