Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat

M Mazo, JJ Gavira, G Abizanda, C Moreno… - Cell …, 2010 - journals.sagepub.com
The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC)
transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect …

Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic …

…, L Cordeu, L Gárate, E San José-Eneriz, G Abizanda… - Cancer research, 2009 - AACR
Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most
important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate …

Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction

M Mazo, V Planat‐Bénard, G Abizanda… - European journal of …, 2008 - Wiley Online Library
Aims: To determine the effect of transplantation of undifferentiated and cardiac pre‐differentiated
adipose stem cells compared with bone marrow mononuclear cells (BM‐MNC) in a …

Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia–reperfusion model

FR Formiga, B Pelacho, E Garbayo, G Abizanda… - Journal of Controlled …, 2010 - Elsevier
The use of pro-angiogenic growth factors in ischemia models has been associated with limited
success in the clinical setting, in part owing to the short lived effect of the injected cytokine…

Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar

…, C Pogontke, MI Castillo, G Abizanda… - Journal of the American …, 2015 - jacc.org
Background : Although efforts continue to find new therapies to regenerate infarcted heart
tissue, knowledge of the cellular and molecular mechanisms involved remains poor. …

Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction

…, S Janssens, M Wu, E Iglesias, G Abizanda… - Circulation, 2020 - Am Heart Assoc
Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process
associated with different types of fibrosis. Recent studies have shown that fibroblasts do …

Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model …

…, I Imbuluzqueta, P Díaz-Herráez, G Abizanda… - Journal of Controlled …, 2014 - Elsevier
Acidic fibroblast growth factor (FGF1) and neuregulin-1 (NRG1) are growth factors involved
in cardiac development and regeneration. Microparticles (MPs) mediate cytokine sustained …

Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction

M Araña, JJ Gavira, E Peña, A González, G Abizanda… - Biomaterials, 2014 - Elsevier
Although transplantation of adipose-derived stem cells (ADSC) in chronic myocardial infarction
(MI) models is associated with functional improvement, its therapeutic value is limited …

[HTML][HTML] Multipotent adult progenitor cells sustain function of ischemic limbs in mice

…, B Pelacho, I Penuelas, G Abizanda… - The Journal of …, 2008 - Am Soc Clin Investig
Despite progress in cardiovascular research, a cure for peripheral vascular disease has not
been found. We compared the vascularization and tissue regeneration potential of murine …

Treatment of reperfused ischemia with adipose-derived stem cells in a preclinical Swine model of myocardial infarction

…, S Hernández, JJ Gavira, G Abizanda… - Cell …, 2012 - journals.sagepub.com
The aim of the study was to determine the long-term effect of transplantation of adipose-derived
stromal cells (ADSCs) in a preclinical model of ischemia/reperfusion (I/R). I/R was …