BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer is characterized by early-onset
colorectal cancer and the occurrence of various other cancers. The recent isolation of …

Background Germ-line mutations in DNA mismatch-repair genes (MSH2, MLH1, PMS1,
PMS2, and MSH6 ) cause susceptibility to hereditary nonpolyposis colorectal cancer. We …

Background & Aims: Lynch syndrome family members have a high risk of developing colorectal
(CRC), endometrial (EC), and other cancers. A large-scale surveillance program was …

The oxidant-antioxidant balance is thought to be important in the initiation, promotion, and
therapy resistance of cancer. In the present study, we assessed the expression of the …

Background & Aims : The adenoma-carcinoma sequence in hereditary nonpolyposis colorectal
cancer (HNPCC) is accelerated. It remains unknown whether the mismatch repair (MMR) …

Recently, complexes of matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) with
lipocalin-2 (neutrophil gelatinase-associated lipocalin) were found in the urine obtained from …

Human colorectal carcinogenesis has been shown previously to be associated with impressive
changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by …

BACKGROUND It has been estimated that the prevalence of carriers of a mutated mismatch
repair (MMR) gene among the general population in Western countries is between 5 and 50 …

The hereditary colonic cancer syndrome without polyposis, hereditary non‐polyposis
colorectal cancer (HNPCC), is usually divided into 2 main categories: hereditary site‐specific …

OBJECTIVES We evaluated the prevalence and characteristics of adenomas in a young
population not genetically predisposed for the development of colorectal cancer (CRC). …