Background Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)
are extremes of a clinically, pathologically, and genetically overlapping disease spectrum…

Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have
been linked to Nasu-Hakola disease, Alzheimer’s disease (AD), Parkinson’s disease, …

Neuronal cytoplasmic and intranuclear aggregates of RNA-binding protein TDP-43 are a
hallmark feature of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) …

TREM 2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐function
mutations of TREM 2 are associated with increased risk of Alzheimer's disease ( AD ). …

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated
with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding …

Genetic analysis revealed the hexanucleotide repeat expansion GGGGCC within the regulatory
region of the gene C9orf72 as the most common cause of familial amyotrophic lateral …

Sequence variations in the triggering receptor expressed on myeloid cells 2 ( TREM 2) have
been linked to an increased risk for neurodegenerative disorders such as Alzheimer's …

Triggering receptor expressed on myeloid cells 2 ( TREM 2) is essential for the transition of
homeostatic microglia to a disease‐associated microglial state. To enhance TREM 2 activity, …

Emerging evidence supports a role for innate immunity and microglia in Alzheimer’s disease
(AD) pathophysiology. However, no marker related to microglia has been included in the …

Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain,
contributes to the development of Alzheimer’s disease (AD). We therefore examined whether …