Mathematical expressions derived from models based on the exponential decline of drug
levels in the body and/or on a linear relationship between the intensity of the elicited effect and …

Salicylate elimination kinetics was studied over a dose range of from 0.25 to 2.0 Gm. of aspirin.
It was found that when the amount of salicylate in the body of normal adult test subjects …

NUMEROUS conflicting reports about the relative efficacy of regular acetylsalicylic acid and
the form in combination with buffering agents have appeared in the literature. The purpose …

It is shown that the apparent volume of distribution at the steady state (V d ) ss in a two‐compartmental
open system cannot be used to relate the drug concentration in the plasma to the …

A hydrophobic tablet lubricant (magnesium stearate) has been found to retard the
dissolution of salicylic acid from model compressed tablets, while a water‐soluble, surface‐active …

The mainstays of caring for patients who have swallowed poison or been given an overdose
of drugs are inhibition of absorption (in acute poisoning after oral injection) or specific …

The purpose of this study was to determine if certain physiologic parameters (plasma
bilirubin concentration and urinary excretion rate of D-glucaric acid) can be used to predict a …

Aspirin is very rapidly absorbed from the gastrointestinal tract when administered as a solution,
and somewhat more slowly when administered in tablets. It is rapidly hydrolyzed in the …

Various surveys have shown that pregnant women frequently take mild analgesics. The
most widely used nonprescription analgesics are aspirin, acetaminophen, and its precursor …

The plateau level of salicylate in the body attained by repetitive administration of fixed doses
of aspirin or sodium salicylate at constant intervals increases more than proportionately with …