Background Whether to perform valve replacement in patients with asymptomatic but severe
aortic stenosis is controversial. Therefore, we studied the natural history of this condition to …

Background The assessment of myocardial viability has been used to identify patients with
coronary artery disease and left ventricular dysfunction in whom coronary-artery bypass …

Background— We sought to assess the outcome of asymptomatic patients with very severe
aortic stenosis. Methods and Results— We prospectively followed 116 consecutive …

Background— The prognostic value of natriuretic peptides in aortic stenosis (AS) remains
unknown. Methods and Results— B-type natriuretic peptide (BNP), N-terminal BNP (NtBNP), …

Several modifiable cardiovascular risk factors such as hypercholesterolemia, smoking,
diabetes, hypertension, and hyperhomocysteinemia are associated with impaired endothelium-…

Aims To define the natural history and predictors of outcome in mild and moderate aortic
stenosis (AS). Methods and results One hundred and seventy-six consecutive asymptomatic …

Background— The management of asymptomatic severe mitral regurgitation remains
controversial. The aim of this study was to evaluate the outcome of a watchful waiting strategy in …

Background— Recently, statins and angiotensin-converting enzyme inhibitors (ACEIs) have
been shown to slow aortic valve calcium accumulation. Although several studies also …

Background— The purpose of this study was to determine whether implementation of recent
guidelines improves in-hospital mortality from acute ST-elevation myocardial infarction (…

Background Left-sided heart disease (LHD) is the most common cause of pulmonary
hypertension (PH). In patients with LHD, elevated left atrial pressure causes a passive increase in …