User profiles for Gerald Hoefler
Gerald HoeflerMedical University Graz Verified email at medunigraz.at Cited by 19292 |
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids (FFAs)
from stored fat requires the enzymatic activity of lipases. We showed that genetic …
from stored fat requires the enzymatic activity of lipases. We showed that genetic …
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate genes involved in energy metabolism and inflammation. For biological activity, PPARs …
regulate genes involved in energy metabolism and inflammation. For biological activity, PPARs …
Adipose triglyceride lipase contributes to cancer-associated cachexia
…, P Vesely, G Haemmerle, R Zechner, G Hoefler - Science, 2011 - science.org
Cachexia is a multifactorial wasting syndrome most common in patients with cancer that is
characterized by the uncontrolled loss of adipose and muscle mass. We show that the …
characterized by the uncontrolled loss of adipose and muscle mass. We show that the …
[HTML][HTML] Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
Background Patients with prostate cancer may present with metastatic or recurrent disease
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the …
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the …
[PDF][PDF] A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis
In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels
in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid leukemia, we …
in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid leukemia, we …
Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting
BACKGROUND: Blood vessel invasion has been associated with poor outcome in colorectal
cancer (CRC), whereas the prognostic impact of lymphatic invasion is less clear. The …
cancer (CRC), whereas the prognostic impact of lymphatic invasion is less clear. The …
Translational regulation mechanisms of AP-1 proteins
The activator protein 1 (AP-1) transcription factor is assembled from jun-jun, jun-fos, or jun-atf
family protein homo- or heterodimers. AP-1 belongs to the class of basic leucine zipper (…
family protein homo- or heterodimers. AP-1 belongs to the class of basic leucine zipper (…
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase
…, A Sevanian, R Zechner, G Hoefler… - Proceedings of the …, 2003 - National Acad Sciences
Increased levels of triglyceride-rich lipoproteins provoke lipid accumulation in the artery wall,
triggering early inflammatory responses central to atherosclerosis like endothelial adhesion …
triggering early inflammatory responses central to atherosclerosis like endothelial adhesion …
[HTML][HTML] Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI …
…, A Lass, R Zimmermann, G Hoefler… - Journal of biological …, 2010 - ASBMB
Comparative gene identification-58 (CGI-58), also designated as α/β-hydrolase domain
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose triglyceride …
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose triglyceride …
[HTML][HTML] Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing
Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as
cetuximab and panitumumab, have evolved to important therapeutic options in metastatic …
cetuximab and panitumumab, have evolved to important therapeutic options in metastatic …