In 120 patients with severe emphysema evaluated for participation in the National Emphysema
Treatment Trial, pulmonary hemodynamics and ventricular function were assessed. …

Background There is notable heterogeneity in the clinical presentation of patients with
COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by …

Rationale: Lung volume reduction surgery (LVRS) has been demonstrated to provide a
functional and mortality benefit to a select group of subjects with chronic obstructive pulmonary …

COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with a median 5-year survival
of ~20%. Current US Food and Drug Administration–approved pharmacotherapies slow …

Computed tomographic based indices of emphysematous lung destruction may highlight
differences in disease pathogenesis and further enable the classification of subjects with …

Rationale: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to
genetic variants. Most genetic studies have been focused on genome-wide common variants …

Senescence is a mechanism associated with aging that alters tissue regeneration by depleting
the stem cell pool. Chronic obstructive pulmonary disease (COPD) displays hallmarks of …

Rationale: Genomic regions identified by genome-wide association studies explain only a
small fraction of heritability for chronic obstructive pulmonary disease (COPD). Alpha-1 …

Background Mild expiratory flow limitation may not be recognized using traditional spirometric
criteria based on the ratio of FEV 1 /FVC. Research Question Does slow vital capacity (…