[PDF][PDF] Positive reinforcing mechanisms between GPR120 and PPARγ modulate insulin sensitivity
…, AR Pessentheiner, O Osborn, N Hah, TJ Chi, GL Tye… - Cell metabolism, 2020 - cell.com
G protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing
effects. But whether these two pathways functionally interact and can be leveraged …
effects. But whether these two pathways functionally interact and can be leveraged …
TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: delayed regeneration of apical epithelial growth factor barrier and the epithelial basement …
RC de Oliveira, G Tye, LP Sampaio, TM Shiju… - Experimental eye …, 2021 - Elsevier
The purpose of this study was to investigate the expression and localization of transforming
growth factor (TGF) β1 and TGFβ2 in rabbit corneas that healed with and without stromal …
growth factor (TGF) β1 and TGFβ2 in rabbit corneas that healed with and without stromal …
[HTML][HTML] PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
…, JH Lee, JM Fredericks, C Poffenberger, G Tye… - Journal of …, 2020 - Springer
Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a
key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory …
key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory …
Evaluation of two potent and selective PET radioligands to image COX-1 and COX-2 in rhesus monkeys
…, C Brouwer, K Henry, E Gallagher, GL Tye… - Journal of Nuclear …, 2018 - Soc Nuclear Med
This study assessed whether the newly developed PET radioligands 11 C-PS13 and 11 C-MC1
could image constitutive levels of cyclooxygenase (COX)-1 and COX-2, respectively, in …
could image constitutive levels of cyclooxygenase (COX)-1 and COX-2, respectively, in …
First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain
…, S Telu, P Singh, MY Cortes, K Henry, GL Tye… - European journal of …, 2020 - Springer
Purpose This study assessed whether the newly developed PET radioligand [ 11 C]PS13,
which has shown excellent in vivo selectivity in previous animal studies, could be used to …
which has shown excellent in vivo selectivity in previous animal studies, could be used to …
Demographic and socioeconomic differences in outpatient ophthalmology utilization in the United States
C Rasendran, G Tye, K Knusel, RP Singh - American journal of …, 2020 - Elsevier
Purpose The purpose was to assess differences in outpatient ophthalmologic usage based
on patient characteristics such as race/ethnicity, income, insurance type, geographical region…
on patient characteristics such as race/ethnicity, income, insurance type, geographical region…
[HTML][HTML] Accommodative exercises to lower intraocular pressure
TJ Stokkermans, JC Reitinger, G Tye, CY Kao… - Journal of …, 2020 - hindawi.com
Purpose. This study investigated how a conscious change in ocular accommodation affects
intraocular pressure (IOP) and ocular biometrics in healthy adult volunteers of different ages. …
intraocular pressure (IOP) and ocular biometrics in healthy adult volunteers of different ages. …
[HTML][HTML] Outflow facility effects of 3 Schlemm's canal microinvasive glaucoma surgery devices
CB Toris, PP Pattabiraman, G Tye… - Ophthalmology …, 2020 - Elsevier
Purpose To study the effect of 3 Schlemm’s canal (SC) microinvasive glaucoma surgery (MIGS)
devices on outflow facility. Design Paired comparisons, randomized design, baseline-…
devices on outflow facility. Design Paired comparisons, randomized design, baseline-…
[Carboxyl‐11C]Labelling of Four High‐Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography
…, JS Liow, SS Zoghbi, A Kowalski, GL Tye… - …, 2018 - Wiley Online Library
Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and
neurodegenerative disorders associated with oxidative stress and neuroinflammation. An …
neurodegenerative disorders associated with oxidative stress and neuroinflammation. An …
Changes in parameters of aqueous humor dynamics throughout life
CB Toris, G Tye, P Pattabiraman - Ocular Fluid Dynamics: Anatomy …, 2019 - Springer
Steady-state intraocular pressure (IOP) results from the interplay of the inflow, outflow, facility,
and pressure of aqueous humor dynamics. A change in any one of these parameters may …
and pressure of aqueous humor dynamics. A change in any one of these parameters may …