β-amyloid plaques (Aβ plaques) in the brain, containing predominantly fibrillary Aβ peptide
aggregates, represent a defining pathologic feature of Alzheimer disease (AD). Imaging …

An investigation of the NiCl 2 (dppe)-, NiCl 2 (dppb)-, NiCl 2 (dppf)-, NiCl 2 (PCy 3 ) 2 -, and
NiCl 2 (PPh 3 ) 2 -catalyzed cross-coupling of the previously unreported aryl mesylates, and …

Florbetapir F-18 is a molecular imaging agent combining high affinity for β-amyloid,
pharmacokinetic properties that allow positron emission tomography (PET) imaging within a …

The genus Mycobacterium comprises significant pathogenic species that infect both humans
and animals. One species within this genus, Mycobacterium tuberculosis, is the primary …

4-Hydroxypyrones belong to an important class of compounds not only because of their
medicinal significance, but also because they represent a common structural feature among …

Encouraged by this calculation we pursued the synthesis of α, β-unsaturated aldehydes that
would serve as precursors to 5. The racemic ester 9 Scheme 3) could be obtained readily in …

Background DNA microarrays have become ubiquitous in biological and medical research.
The most difficult problem that needs to be solved is the design of DNA oligonucleotides that (…

A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro
evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate …

The compounding challenges of low signal, high background, and uncertain targets plague
many metagenomic sequencing efforts. One solution has been DNA capture, wherein …

1190 Objectives Beta-amyloid plaques in the brain is a major risk factor for Alzheimer’s
disease. AV-45 (florpiramine F-18) is a plaques-specific imaging agent currently under a phase …