Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous
cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG levels, …

We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like
receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing …

To better understand the role of bromodomain and extra-terminal domain (BET) proteins in
epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and …

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination
of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has …

The sigma-1 receptor (σ 1 R) is a unique intracellular protein. σ 1 R plays a major role in
various pathological conditions in the central nervous system (CNS), implicated in several …

A modified alcohol-enhanced 18F-fluorodeboronation has been developed for the radiosyntheses
of [18F]JNJ-46356479 and [18F]FITM. Unlike the [18F]KF/K222 approach, this method …

Introduction: The adenosine A 2A receptor (A 2A R) represents a drug target for a wide spectrum
of diseases. Approaches for targeting this membrane-bound protein have been greatly …

Two tandem bromodomains (BD1 and BD2) of bromodomain and extraterminal domain (BET)
family proteins have shown distinct roles in mediating gene transcription and expression. …

Purpose Castration-resistant prostate cancer (CRPC) is the most common cause of death in
men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, …

The orexin receptors (OXRs) have been involved in multiple physiological and neuropsychiatric
functions. Identification of PET imaging probes specifically targeting OXRs enables us to …