Fluorodeoxyglucose positron emission tomography (PET) studies have found that patients
with Alzheimer's dementia (AD) have abnormally low rates of cerebral glucose metabolism in …

ContextDeficits in cerebral glucose utilization have been identified in patients with cognitive
dysfunction attributed to various disease processes, but their prognostic and diagnostic …

Fibrillar amyloid-beta (Aβ) is found in the brains of many cognitively normal older people.
Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used …

The apolipoprotein E (APOE) ɛ4 allele is the best established genetic risk factor for late-onset
Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-…

Background We have previously characterised functional brain abnormalities in young
adults at genetic risk for late-onset Alzheimer's disease. To gain further knowledge on the …

OBJECTIVE: It is well established that regional cerebral metabolic rates for glucose assessed
by [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with …

A higher prevalence of dementia in individuals with fewer years of education has suggested
that education may protect against Alzheimer's disease (AD). We tested whether individuals …

Background The APOE ε4 allele is associated with the risk of late-onset Alzheimer's disease.
The age at which memory decline diverges among persons who are homozygous for the …

Obiective: Clinical heterogeneity in Alzheimer's disease has been uidely observed. One
factor that may influence the expression of dementia in Alzheimer's disease is premorbid …

The current study tested the accuracy of primary MRI and cerebrospinal fluid (CSF) biomarker
candidates and neuropsychological tests for predicting the conversion from mild cognitive …