To seek evidence that the nonhuman primate arterial wall, as it ages in the absence of
atherosclerosis, exhibits alterations in pathways that are involved in the pathogenesis of …

The sympathetic nervous system is designed to respond to stress. Adenylyl cyclase (AC) is
the keystone of sympathetic transmission, yet its role in response to acute overload in the …

To determine the effects of aging on vasoactivity in a primate model (Macaca fascicularis), 13
young male monkeys (aged 7.1±0.4 years) and 9 old male monkeys (aged 19.8±0.6 years) …

Mitogen-activated protein kinase kinase kinase (MEKK1) mediates activation of c-Jun NH 2 -terminal
kinase (JNK). Although previous studies using cultured cardiac myocytes have …

Left ventricular hypertrophy (LVH) is a compensatory mechanism to cope with pressure overload.
Recently, a calcineurin pathway mediating LVH and its prevention by cyclosporine was …

In a genetically engineered mouse line with disruption of type 5 adenylyl cyclase (AC5 −/− ),
a major cardiac isoform, there was no compensatory increase in other isoforms of AC in the …

We investigated efficacy and safety of implantation of autologous bone marrow mononuclear
cells plus platelets, including endothelial progenitor cells (EPCs), for recovering refractory …

The vascular endothelial function is impaired in the very early stage of atherosclerosis in
diabetic patients. The goal of this study was to identify the mechanism underlying the …

Aim Restrictions such as physical distancing and online learning for college students were
implemented due to the COVID‐19 pandemic. Owing to this, students may experience …

BACKGROUND: Platelet-rich plasma (PRP) contains numerous growth factors that have
angiogenic activities. However, the PRP-induced angiogenesis is limited by the short half-life …