Self-renewing tissue-resident macrophages are thought to be exclusively derived from
embryonic progenitors. However, whether circulating monocytes can also give rise to such …

Cells of the monocyte–macrophage lineage play a central role in the orchestration and
resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response …

Alternatively activated macrophages (aaMφ) display molecular and biological characteristics
that differ from those of classically activated macrophages (caMφ). Recently, we described …

Mononuclear phagocytes often function as control switches of the immune system, securing
the balance between pro- and anti-inflammatory reactions. For this purpose and depending …

Genes such as Ym1 and Arginase, which are known to be regulated by IL-4 in murine
macrophages (2, 3), were not detected in our study. We speculated that these differences may …

Depending on the cytokine environment, macrophages can differentiate into distinct subsets
that perform specific immunological roles. In this regard, the functions of macrophages …

Tumor-associated macrophages (TAM) are an important component of the tumor stroma
and exert several tumor-promoting activities. Strongly pro-angiogenic TAMs that reside in …

Molecular markers, especially surface markers associated with type II, cytokine-dependent,
alternatively activated macrophages (aaMF), remain scarce. Besides the earlier documented …

The current review article describes the functional relationship between tumor-associated
macrophages (TAM) as key cellular contributors to cancer malignancy on the one hand and …

Although it is well-established that macrophages can occur in distinct activation states, the
molecular characteristics of differentially activated macrophages, and particularly those of …