User profiles for Gary D. Luker
Gary LukerUniversity of Michigan Verified email at umich.edu Cited by 16392 |
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
CXCR4 regulates growth of both primary and metastatic breast cancer
…, JL Prior, E Jackson, D Piwnica-Worms, GD Luker - Cancer research, 2004 - AACR
The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
Natural interferon-producing cells (IPCs) specialize in the production of high levels of type 1
interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate …
interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate …
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
Z Miao, KE Luker, BC Summers… - Proceedings of the …, 2007 - National Acad Sciences
Chemokines and chemokine receptors have been posited to have important roles in several
common malignancies, including breast and lung cancer. Here, we demonstrate that …
common malignancies, including breast and lung cancer. Here, we demonstrate that …
Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly
mediated through protein–protein interactions as well as reversible phosphorylation of proteins. …
mediated through protein–protein interactions as well as reversible phosphorylation of proteins. …
Optical imaging: current applications and future directions
Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful
new modalities for molecular imaging in disease and therapy. Combining innovative …
new modalities for molecular imaging in disease and therapy. Combining innovative …
Functions of CXCL12 and CXCR4 in breast cancer
The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 were first identified in the
context of trafficking and homeostasis of immune cells, such as T lymphocytes. …
context of trafficking and homeostasis of immune cells, such as T lymphocytes. …
[HTML][HTML] Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells
Background The ability to properly model intravascular steps in metastasis is essential in
identifying key physical, cellular, and molecular determinants that can be targeted …
identifying key physical, cellular, and molecular determinants that can be targeted …
[PDF][PDF] Targeting breast cancer stem cell state equilibrium through modulation of redox signaling
…, D Triner, S McDermott, SD Merajver, GD Luker… - Cell metabolism, 2018 - cell.com
Although breast cancer stem cells (BCSCs) display plasticity transitioning between quiescent
mesenchymal-like (M) and proliferative epithelial-like (E) states, how this plasticity is …
mesenchymal-like (M) and proliferative epithelial-like (E) states, how this plasticity is …
Near-infrared fluorescent proteins
D Shcherbo, II Shemiakina, AV Ryabova, KE Luker… - Nature …, 2010 - nature.com
Fluorescent proteins with emission wavelengths in the near-infrared and infrared range are
in high demand for whole-body imaging techniques. Here we report near-infrared dimeric …
in high demand for whole-body imaging techniques. Here we report near-infrared dimeric …