User profiles for Gary A Ulaner
Gary UlanerHoag Family Cancer Institute, Newport Beach, California Verified email at hoag.org Cited by 8964 |
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT …
GA Ulaner, JF Hu, TH Vu, LC Giudice, AR Hoffman - Cancer research, 1998 - AACR
The correlation between telomerase activity, telomere lengths, and cellular replicative
capacity has led to the theory that maintenance of telomere lengths by telomerase acts as a …
capacity has led to the theory that maintenance of telomere lengths by telomerase acts as a …
HER kinase inhibition in patients with HER2-and HER3-mutant cancers
Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively)
are found in a wide range of cancers. Preclinical modelling suggests that a subset of these …
are found in a wide range of cancers. Preclinical modelling suggests that a subset of these …
[HTML][HTML] Ado-trastuzumab emtansine for patients with HER2-mutant lung cancers: results from a phase II basket trial
Purpose Human epidermal growth factor receptor 2 (HER2, ERBB2)–activating mutations
occur in 2% of lung cancers. We assessed the activity of ado-trastuzumab emtansine, a HER2-…
occur in 2% of lung cancers. We assessed the activity of ado-trastuzumab emtansine, a HER2-…
Efficacy of MEK inhibition in patients with histiocytic neoplasms
EL Diamond, BH Durham, GA Ulaner, E Drill, J Buthorn… - Nature, 2019 - nature.com
Histiocytic neoplasms are a heterogeneous group of clonal haematopoietic disorders that are
marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway 1 , 2 …
marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway 1 , 2 …
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers
T-DM1 is clinically effective in lung cancers with amplification of or mutations in ERBB2 . This
activity is enhanced by cotreatment with irreversible pan-HER inhibitors, or ADC switching …
activity is enhanced by cotreatment with irreversible pan-HER inhibitors, or ADC switching …
Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
GA Ulaner, JF Hu, TH Vu, H Oruganti… - … journal of cancer, 2000 - Wiley Online Library
Telomerase extends telomeric repeats at the ends of linear chromosomes, thereby
prolonging the replicative capacity of cells. To investigate possible regulatory mechanisms of …
prolonging the replicative capacity of cells. To investigate possible regulatory mechanisms of …
Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site
GA Ulaner, TH Vu, T Li, JF Hu, XM Yao… - Human molecular …, 2003 - academic.oup.com
The adjacent insulin-like growth factor 2 (IGF2) and H19 genes are imprinted in most
normal human tissues, but imprinting is often lost in tumors. The mechanisms involved in …
normal human tissues, but imprinting is often lost in tumors. The mechanisms involved in …
Detection of HER2-positive metastases in patients with HER2-negative primary breast cancer using 89Zr-trastuzumab PET/CT
Our objective was to determine whether imaging with a human epidermal growth factor
receptor 2 (HER2)–targeted PET tracer can detect HER2-positive metastases in patients with …
receptor 2 (HER2)–targeted PET tracer can detect HER2-positive metastases in patients with …
IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch
T Li, TH Vu, GA Ulaner, E Littman… - Molecular human …, 2005 - academic.oup.com
Recent studies suggest that IVF and assisted reproduction technologies (ART) may result in
abnormal genomic imprinting, leading to an increased frequency of Angelman syndrome (AS…
abnormal genomic imprinting, leading to an increased frequency of Angelman syndrome (AS…
Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma
There are two telomere maintenance mechanisms (TMMs) in human tumors, telomerase
activation (TA) and, more rarely, the process termed alternative lengthening of telomeres (ALT). …
activation (TA) and, more rarely, the process termed alternative lengthening of telomeres (ALT). …