Background: The Hsp90s contain a conserved pocket that binds ATP/ADP and plays an
important role in the regulation of chaperone function. Occupancy of this pocket by several …

Hsp90 is a chaperone required for the conformational maturation of certain signaling proteins
including Raf, cdk4, and steroid receptors. Natural products and synthetic small molecules …

Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple
oncogenic pathways. As such, Hsp90 inhibition is a promising anti-cancer strategy. Several …

Most cancers are characterized by multiple molecular alterations, but identification of the key
proteins involved in these signaling pathways is currently beyond reach. We show that the …

The identification of somatic activating mutations in JAK2 (refs 1 ) and in the thrombopoietin
receptor gene (MPL) 5 in most patients with myeloproliferative neoplasm (MPN) led to the …

Although androgen receptor (AR)-mediated signaling is central to prostate cancer, the ability
to modulate AR signaling states is limited. Here we establish a chemical genomic approach …

Transient, multi-protein complexes are important facilitators of cellular functions. This
includes the chaperome, an abundant protein family comprising chaperones, co-chaperones, …

Arylthioindoles (ATIs) that possess a 3-methoxyphenylthio or a 3,5-dimethoxyphenylthio
moiety at position 2 of the indole ring were effective tubulin assembly inhibitors, but weak …

Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen,
progesterone, and HER2 receptors. Because of the absence of identified targets and targeted …

The Hsp90 multichaperone complex has important roles in the development and progression
of malignant transformation. Several small-molecule inhibitors of Hsp90 of diverse …