Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease

S Darvesh, MK Cash, GA Reid, E Martin… - … of Neuropathology & …, 2012 - academic.oup.com
Histochemical analysis of Alzheimer disease (AD) brain tissues indicates that butyrylcholinesterase
(BuChE) is present in β-amyloid (Aβ) plaques. The role of BuChE in AD pathology is …

[HTML][HTML] Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model

GA Reid, S Darvesh - Neuroscience, 2015 - Elsevier
In Alzheimer’s disease (AD), numerous β-amyloid (Aβ) plaques are associated with
butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, …

Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites

…, P Stafford, R Boudreau, GA Reid… - … Research & Clinical …, 2022 - Wiley Online Library
Introduction Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation
concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in …

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer's disease

…, KL Forrestall, H Maillet, GA Reid… - Journal of Enzyme …, 2023 - Taylor & Francis
Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer
disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have …

Synthesis and preliminary evaluation of phenyl 4-123I-iodophenylcarbamate for visualization of cholinesterases associated with Alzheimer disease pathology

IR Macdonald, GA Reid, IR Pottie… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Acetylcholinesterase and butyrylcholinesterase accumulate with brain β-amyloid (Aβ) plaques
in Alzheimer disease (AD). The overall activity of acetylcholinesterase is found to decline …

Synthesis and preliminary evaluation of piperidinyl and pyrrolidinyl iodobenzoates as imaging agents for butyrylcholinesterase

…, GA Reid, EE Joy, IR Pottie, G Matte… - Molecular imaging and …, 2011 - Springer
Purpose The purpose of this study is to synthesize and evaluate specific agents for molecular
imaging of butyrylcholinesterase (BuChE), known to be associated with neuritic plaques …

Photochemical oxidation of tetracycline in aqueous solution

…, JF McKellar, GO Phillips, AG Reid - Journal of the Chemical …, 1979 - pubs.rsc.org
Irradiation of an aqueous solution of tetracycline at pH 9 with uv light from a medium pressure
mercury lamp (filtered through Pyrex glass to give wavelengths >290 nm) produces a red …

The expression of DJ‐1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

…, AE Kingsbury, MR Cookson, AR Reid… - Brain, 2004 - academic.oup.com
Two mutations in the DJ‐1 gene on chromosome1p36 have been identified recently to
cause early‐onset, autosomal recessive Parkinson’s disease. As no information is available …

[HTML][HTML] Assessment of second-line antiretroviral regimens for HIV therapy in Africa

NI Paton, C Kityo, A Hoppe, A Reid… - New England journal …, 2014 - Mass Medical Soc
Background The efficacy and toxic effects of nucleoside reverse-transcriptase inhibitors (NRTIs)
are uncertain when these agents are used with a protease inhibitor in second-line …

Mechanical, thermal insulation, thermal resistance and acoustic absorption properties of geopolymer foam concrete

Z Zhang, JL Provis, A Reid, H Wang - Cement and Concrete Composites, 2015 - Elsevier
This study reports the synthesis and characterization of geopolymer foam concrete (GFC). A
Class F fly ash with partial slag substitution was used for GFC synthesis by mechanical …