Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of
severe hypertension, feature constitutive hormone production and unrestrained cell proliferation…

Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining
hormone aldosterone and are a common cause of severe hypertension. Recurrent mutations …

Background. Population-based screenings for primary hyperparathyroidism have failed to
systematically use intact parathyroid hormone (PTH) values for diagnosis, to explore …

Objective: The surgical management of primary hyperparathyroidism (PHPT) has undergone
considerable advances over the past two decades. The purpose of this report is to review …

Background Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune
disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent …

We have evaluated survival and tumor-related symptoms in the presence of mesenteric lymph
node and liver metastases in relation to surgical procedures in 314 patients (148 women, …

We used riboprobes and monoclonal antibodies to characterize tissue distribution of the
human 550-kD homologue to gp330/megalin, primarily identified in the rat kidney. Human …

Background Small intestinal neuroendocrine tumors (SI-NETs) are uncommon, with an annual
incidence of about 1 per 100,000 individuals. The primary tumor (PT) is generally small, …

Active vitamin D, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], plays a pivotal role in calcium
homeostasis and bone metabolism. Circulating levels of 1,25(OH) 2 D 3 are thought to be …

Neuroendocrine tumours of the gastrointestinal tract and pancreas present a major challenge
to physicians in their recognition and treatment requirements, and surgical treatment of …