Aim: To understand the characteristics of peripheral immunity in patients with Parkinson's
disease (PD), we investigated the natural killer (NK) cell activity and lymphocyte …

Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and
concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), …

Tau deposits is a core feature of neurodegenerative disorder following traumatic brain injury
(TBI). Despite ample evidence from post-mortem studies demonstrating exposure to both …

Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, including sleep
and autonomic dysfunctions, controlled by circadian regulation. To evaluate the alteration …

Background [ 11 C]pyridinyl‐butadienyl‐benzothiazole 3 is a PET imaging agent designed
for capturing pathological tau aggregates in diverse neurodegenerative disorders, and would …

Objective Apathy is a common neuropsychological symptom in Alzheimer’s disease (AD),
and previous studies demonstrated that neuronal loss and network disruption in some brain …

Objectives Neuropsychiatric symptom could be useful for detecting patients with prodromal
dementia. Similarities and differences in the NPSs between preclinical/prodromal …

Objective: Central autonomic impairment due to acute cerebral infarction is known to lead to
excessively high blood pressure and tachycardia. The mechanism by which these …

Background Sleep has been reported to be an important factor in bone metabolism, and
sympathetic nervous system activity has been reported to regulate bone metabolism. In this …

Objective To characterize the distribution of tau pathology in patients with amyotrophic lateral
sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET …