Background Olaparib has shown significant clinical benefit as maintenance therapy in
women with newly diagnosed advanced ovarian cancer with a BRCA mutation. The effect of …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

PURPOSE About one third of patients with hormone receptor–positive, human epidermal
growth factor receptor 2–negative breast cancer who have residual invasive disease after …

The recent development of quinoline-based PET tracers that act as fibroblast-activation-protein
inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of …

Background The development of anti-HER2 antibody–drug conjugates opens new therapeutic
options for patients with breast cancer, including patients with low expression of HER2. …

Genome-wide association studies (GWAS) and large-scale replication studies have identified
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …

Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …

Exosomes are membrane vesicles that are released from many different cell types. Tumor
derived-exosomes play a role in immune suppression. We hypothesized that in ovarian …