Improved detection of transosseous meningiomas using 68Ga-DOTATATE PET/CT compared with contrast-enhanced MRI

…, PM Kazmierczak, FJ Vettermann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
68 Ga-DOTATATE PET/CT enables detection of meningioma tissue based on somatostatin
receptor 2 expression. Transosseous extension of intracranial meningiomas is known to be …

[HTML][HTML] Towards standardization of 18F-FET PET imaging: do we need a consistent method of background activity assessment?

M Unterrainer, F Vettermann, M Brendel, A Holzgreve… - EJNMMI research, 2017 - Springer
Background PET with O-(2- 18 F-fluoroethyl)-L-tyrosine ( 18 F-FET) has reached increasing
clinical significance for patients with brain neoplasms. For quantification of standard PET-…

[HTML][HTML] [18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy

…, G Rohrer, C Zach, F Vettermann… - Frontiers in Aging …, 2018 - frontiersin.org
Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder characterized
by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells of the …

Simpson grade revisited–intraoperative estimation of the extent of resection in meningiomas versus postoperative somatostatin receptor positron emission …

M Ueberschaer, FJ Vettermann, R Forbrig… - …, 2021 - journals.lww.com
BACKGROUND Surgeon's intraoperative estimation of meningioma extent of resection (Simpson
Grade, SG) is widely used as a prognostic factor for recurrence. However, the validity of …

Non-invasive prediction of IDH-wildtype genotype in gliomas using dynamic 18F-FET PET

F Vettermann, B Suchorska, M Unterrainer… - European journal of …, 2019 - Springer
Purpose According to the updated WHO classification of gliomas with its emphasis on
molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure …

Characterization of diffuse gliomas with histone H3-G34 mutation by MRI and dynamic 18F-FET PET

FJ Vettermann, J Felsberg, G Reifenberger… - Clinical Nuclear …, 2018 - journals.lww.com
Background Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the
H3 histone family 3A protein represent a very rare, distinct subgroup of IDH–wild type …

Photopenic defects on O-(2-[18F]-fluoroethyl)-L-tyrosine PET: clinical relevance in glioma patients

…, G Stoffels, M Rapp, P Lohmann, F Vettermann… - Neuro …, 2019 - academic.oup.com
Background O-(2-[ 18 F]-fluoroethyl)-L-tyrosine (FET) PET has a sensitivity of more than 90%
to detect gliomas. In the remaining small fraction of gliomas without increased tracer uptake…

[HTML][HTML] Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and …

FJ Vettermann, S Harris, J Schmitt, M Unterrainer… - Life, 2021 - mdpi.com
TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP),
resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical …

[HTML][HTML] L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

FJ Vettermann, C Diekmann, L Weidner, M Unterrainer… - EJNMMI research, 2021 - Springer
Background O-(2-[ 18 F]-fluoroethyl)-L-tyrosine ( 18 F-FET) is a highly sensitive PET tracer
for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-…

Relationship between body mass index, ApoE4 status, and PET-based amyloid and neurodegeneration markers in amyloid-positive subjects with normal cognition or …

…, M Brendel, J Sauerbeck, F Vettermann… - Journal of …, 2018 - content.iospress.com
Body weight loss in late-life is known to occur at a very early stage of Alzheimer’s disease (AD).
Apolipoprotein E4 (ApoE4) represents a major genetic risk factor for AD and is linked to …