The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging

F Beekman, F van der Have - European journal of nuclear medicine and …, 2007 - Springer
Today the majority of clinical molecular imaging procedures are carried out with single-photon
emitters and gamma cameras, in planar mode and single-photon emission computed …

U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice

FJ Beekman, F van der Have… - Journal of Nuclear …, 2005 - Soc Nuclear Med
A major advance in biomedical science and diagnosis was accomplished with the development
of in vivo techniques to image radiolabeled molecules, but limited spatial resolution has …

U-SPECT-II: an ultra-high-resolution device for molecular small-animal imaging

F Van Der Have, B Vastenhouw… - Journal of Nuclear …, 2009 - Soc Nuclear Med
We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of
murine organs down to resolutions of less than half a millimeter and high-resolution total-body …

VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET

MC Goorden, F van der Have, R Kreuger… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but
require 2 separate imaging systems. This paper introduces a Versatile Emission Computed …

System calibration and statistical image reconstruction for ultra-high resolution stationary pinhole SPECT

F van der Have, B Vastenhouw… - IEEE transactions on …, 2008 - ieeexplore.ieee.org
For multipinhole single-photon emission computed tomography (SPECT), iterative
reconstruction algorithms are preferred over analytical methods, because of the often complex …

Quarter-Millimeter-Resolution Molecular Mouse Imaging with U-SPECT+

O Ivashchenko, F van der Have, JL Villena… - Molecular …, 2015 - journals.sagepub.com
… in van der Have and colleagues and Goorden and colleagues. In addition, detailed
attenuation correction was added based on either optical or x-ray CT images to provide absolute …

Ultra-high-sensitivity submillimeter mouse SPECT

O Ivashchenko, F van der Have… - Journal of Nuclear …, 2015 - Soc Nuclear Med
… SPECT system using a collimator that aims to have a high sensitivity and still allow
submillimeter-… Frans van der Have is a shareholder of MILabs. No other potential conflict of interest …

Photon-counting gamma camera based on an electron-multiplying CCD

…, AH Westra, I Moody, F van der Have… - IEEE transactions on …, 2005 - ieeexplore.ieee.org
We have developed a compact ultra-high-resolution gamma camera (UGC), based on an
electron-multiplying charge-coupled device (EMCCD) coupled to a columnar CsI(Tl) scintillator…

[HTML][HTML] Targeted multi-pinhole SPECT

…, B Vastenhouw, F Van Der Have… - European journal of …, 2011 - Springer
Purpose Small-animal single photon emission computed tomography (SPECT) with focused
multi-pinhole collimation geometries allows scanning modes in which large amounts of …

Performance assessment of a preclinical PET scanner with pinhole collimation by comparison to a coincidence-based small-animal PET scanner

…, M Shirmohammad, F van der Have… - Journal of Nuclear …, 2014 - Soc Nuclear Med
PET imaging of rodents is increasingly used in preclinical research, but its utility is limited by
spatial resolution and signal-to-noise ratio of the images. A recently developed preclinical …